王琳琳
王琳琳

姓名:王琳琳
职称/头衔:硕士
所属科室:生殖免疫科
从业年限:
技术专长:早孕期免疫细胞对胚胎的耐受机制,以及免疫细胞在复发性流产患者中的调控机制

个人简介

  暨南大学硕士,深圳中山泌尿外科医院生殖医学临床研究中心研究实习员,长期从事不孕症及生殖障碍相关诊疗策略研究,主要研究方向为感染、免疫、代谢与生殖障碍研究,具有丰富的医学基础科研背景。

  研究内容:

  从事不孕症及生殖障碍相关诊疗策略研究,主要研究方向为感染、免疫、代谢与生殖障碍研究。

  学术成果:

  主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序):

  1. 深圳市科技创新委基础研究项目、JCYJ20190813161010761、滋养层细胞与母胎界面巨噬细胞极化的相互作用及机制研究、2020/08-2023/08、58 万,在研、参与。

  2. 广东省自然科学基金面上项目、2019A1515011315、IGF-1 通过上调子宫基质细胞丙酮酸激酶的表达促进蜕膜化的机制研究、2019/10-2022/09、25 万,在研、参与。

  3. 国家自然科学基金面上项目、21577049、三苯基锡酶催化转化的量子特性和分子机制、2016/01-2019/12、78 万,结题、参与。

  4. 广东省省级科技计划项目、2014A020216013、水体有机锡和多溴联苯醚复合污染处理菌剂与处理技术、2015/05-2017/04、20 万,结题、参与。

  一、期刊论文

  1. 第一作者或通讯作者论文

  (1) Linlin Wang#, Longfei Li#, Chunyu Huang, Lianghui Diao, Ruochun Lian, Yuye Li, Shan Xiao, Xiuyu Hu, Meilan Mo* and Yong Zeng*. Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro fertilization treatment. Fertility and sterility. 2019, 112(2):250-257. (#: co-first author)

  (2) Longfei Li#, Linlin Wang#, Chunyu Huang, Lianghui Diao, Yongnu Zhang, Xu Zhang, Jian Xu and Yong Zeng*. Chronic hepatitis B infection alters peripheral immune response in women with reproductive failure. American Journal of Reproductive Immunology. 2019, 81(3): e13083. (#: co-first author)

  (3) Linlin Wang, Wenying Yi, Jinshao Ye*, Huaming Qin, Yan Long, Meng Yang, Qusheng Li. Interactions among triphenyltin degradation, phospholipid synthesis and membrane characteristics of Bacillus thuringiensis in the presence of d-malic acid. Chemosphere. 2017, 169:403–412.

  (4) Linlin Wang, Jinshao Ye*, Huase Ou, Huaming Qin, Yan Long, Jing Ke. Triphenyltin recognition by primary structures of effector proteins and the protein network of Bacillus thuringiensis during the triphenyltin degradation process. Scientific reports. 2017, 7(1): 4133.

  (5) Linlin Wang, Litao Tang, Ran Wang, Xiaoya Wang, Jinshao Ye*, Yan Long*. Biosorption and degradation of decabromodiphenyl ether by Brevibacillus brevis and the influence of decabromodiphenyl ether on cellular metabolic responses. Environmental Science and Pollution Research. 2016, 23:5166–5178.

  2. 既非第一作者又非通讯作者论文

  (1) Su Liu, Meilan Mo, Shan Xiao, Longfei Li, Xiuyu Hu, Ling Hong, Linlin Wang, Ruochun Lian, Chunyu Huang, Yong Zeng, Lianghui Diao. Pregnancy outcomes of women with polycystic ovary syndrome for the first in vitro fertilization treatment: A retrospective cohort study with 7678 patients. Frontiers in Endocrinology. June 08, 2020. DOI: 10.22541/au.159164145.55272265.

  (2) Lianghui Diao, Songchen Cai, Chunyu Huang, Longfei Li, Shuyi Yu, Linlin Wang, Su Liu, Yuye Li*, Yong Zeng*. New endometrial immune cell-based score (EI-score) for the prediction of implantation success for patients undergoing IVF/ICSI, Placenta (2020), doi: https://doi.org/10.1016/j.placenta.2020.07.025.

  (3) Litao Tang, Linlin Wang, Huase Ou, Qusheng Li, Jinshao Ye*, Hua Yin*. Correlation among phenyltins molecular properties, degradation and cellular influences on Bacillus thuringiensis in the presence of biosurfactant. Biochemical Engineering Journal. 2016, 105: 71–79.

  (4) Huase Ou, Juan Liu, Jinshao Ye*, Linlin Wang, Naiyun Gao, Jing Ke. Degradation of tris(2-chloroethyl) phosphate by ultraviolet-persulfate: Kinetics, pathway and intermediate impact on proteome of Escherichia coli. Chemical Engineering Journal. 2017, 308: 386–395.

  (5) Jinshao Ye, Juan Liu, Huase Ou*, Linlin Wang. Degradation of ciprofloxacin by 280 nm ultraviolet-activated persulfate: Degradation pathway and intermediate impact on proteome of Escherichia coli. Chemosphere. 2016, 165: 311–319.

  (6) Jiawen Ma, Litao Tang, Hua Yin, Linlin Wang, Xiruo Wang, Jinshao Ye*. Triphenyltin degradation and its correlation with cellular ion release by Bacillus cereus. Source Journal of Bioremediation. 2014, 1: 1–9.

  (7) Jinshao Ye*, Hua Yin, Hui Peng, Jieqiong Bai, Danping Xie, Linlin Wang, Biosorption and biodegradation of triphenyltin by Brevibacillus brevis. Bioresource Technology. 2013, 129: 236–241.

  二、会议摘要

  (1) Linlin Wang, Longfei Li, Juanhua Wu, Cong Chen and Yong Zeng*. Higher macrophages infiltration is correlated with poor outcome in early pregnancy. American Journal of Reproductive Immunology. Shanghai, China. 2018, 80 S1 P27.

  (2) Longfei Li, Linlin Wang, Yuanchang Zhu, Cong Chen, Juanhua Wu and Yong Zeng*. Human placental Hofbauer cells are markedly decreased in spontaneous miscarriage. American Journal of Reproductive Immunology. Shanghai, China. 2018, 80 S1 P13.

  (3) Longfei Li, Linlin Wang, Chunyu Huang, Juanhua Wu, Yaya Wu and Yong Zeng*. Immune profiles in the endometrium during implantation window and in the decidua of early pregnancy. Journal of Reproductive Immunology. 2018, 128: 57.

  (4) 王琳琳,叶锦韶*. D-苹果酸对苏云金芽孢杆菌代谢及三苯基锡降解的作用机制. 第八届全国环境化学大会,中国广州,2015. (口头报告)

  (5) Jinshao Ye and Linlin Wang. Relattion among Triphenyltin Recognition, Degradation, Ion Metabolism and Effective Proteins of Bacillus thuringiensis. The 8th International Conference on Environmental Science and Technology. Houston, Texas, USA–June 6–10, 2016.

  (6) Litao Tang, Wenying Yi, Linlin Wang, Jinshao Ye*. Cellular metabolism responses of Bacillus thuringiensis during triphenyltin biodegradation process. The 1st International Conference on Environmental Pollution and Health. Guangzhou, China. 2015, 6: 2–4.

  三、授权专利

  (1) 叶锦韶;王琳琳. 一种双层电泳胶染色装置和自动化电泳胶染色装置、ZL 2018 2 1131681.5、2019-02-01、实用新型。