刁梁辉
刁梁辉

姓名:刁梁辉
职称/头衔:副院长/生殖医学临床研究中心主任
所属科室:生殖医学临床研究中心/生殖免疫中心
从业年限:
技术专长:子宫内膜接受性的生物标记物筛选,子宫内膜微环境的免疫学调控机制及反复胚胎着床失败的临床干预策略

个人简介

  中山大学博士,德国汉堡大学博士后。深圳中山泌尿外科医院生殖医学临床研究中心主任,锦欣医疗科技创新中心CEO,德国汉堡大学附属艾本德医院(UKE)母胎医学客座科学家。擅长领域:生殖免疫代谢、子宫内膜微环境及临床干预策略。社会任职:美国生殖免疫协会(ASRM)获奖委员会委员,中国免疫学会会员,广东省免疫协会生殖免疫专业委员会委员,《中华生殖与避孕杂志》通讯编委,《Seminars in Immunopathology》《Journal of Reproductive Immunology》和 《American Journal of Reproductive Immunology》审稿专家。

  研究方向:

  1、复发性流产和反复种植失败患者子宫内膜容受性标记物筛选;2、妊娠早期免疫代谢重编程对妊娠的建立及维持的机制;3、围着床期子宫内膜微环境的免疫调控机制及临床干预策略。

  学术成果:

  主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序):

  1、 深圳市自然科学基金、JCYJ20190813161801676、母胎界面DC细胞和T细胞代谢功能适应性调节的分子机制、2020/08-2023/08,20万,在研,主持。

  2、 国家自然科学基金青年项目、81701529、HIF-1α与雌激素协同调控Tregs功能和子宫内膜微环境的机制研究、2018/01-2020/12,20万,在研、主持。

  3、 广东省科技发展专项资金项目、2017A020214006、子宫驻留调节性T细胞参与调控免疫微环境和胚胎种植的机制研究、2017/01-2019/12,30万,结题,主持。

  4、 默克雪兰诺--中国生殖医学研究基金、hCG对母胎界面Treg聚集的调控及其与反复种植失败的相关性研究、 2016/01-2017/12、20万,结题、主持。

  5、 深圳市科技创新委基础研究项目、JCYJ20140415114504394、Treg在种植窗期活化迁移的调控因素及其信号通路、2014/09-2016/09、20万,结题、主持。

  代表性研究成果和学术奖励一、期刊论文

  1. 第一作者或通讯作者论文

  (1) Su Liu(#), Meilan Mo, Shan Xiao, Longfei Li, Xiuyu Hu, Ling Hong, Linlin Wang, Ruochun Lian, Chunyu Huang, Yong Zeng* and Lianghui Diao*. Pregnancy outcomes of women with polycystic ovary syndrome for the first in vitro fertilization treatment: A retrospective cohort study with 7678 patients. Front. Endocrinol. | doi: 10.3389/fendo. 2020. 575337

  (2) Diao, Lianghui(#), Songchen Cai(#), Chunyu Huang, Longfei Li, Shuyi Yu, Linlin Wang, Su Liu, Yuye Li(*), and Yong Zeng(*). New Endometrial Immune Cell-Based Score (Ei-Score) for the Prediction of Implantation Success for Patients Undergoing IVF/ICSI, Placenta (2020) 99, 180-188.

  (3) Diao, Liang-Hui,Li, Guan-Gui,Zhu, Yuan-Chang,Tu, Wen-Wei,Huang, Chun-Yu , Lian, Ruo-Chun,Chen, Xian,Li, Yu-Ye,Zhang, Tao,Huang, Yong,Zeng, Yong(*), Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells, Am J Reprod Immunol,2017.01.03,77(3):e12618

  (4) Ding, Jin-Li(#) ,Diao, Liang-Hui(#) ,Yin, Tai-Lang,Huang, Chun-Yu ,Yin, Biao, Chen, Cong,Zhang, Yi,Li, Jie,Cheng, Yan-Xiang,Zeng, Yong(*),Yang, Jing(*),Aberrant expressions of endometrial Id3 and CTLA-4 are associated with unexplained repeated implantation failure and recurrent miscarriage,Am J Reprod Immunol,2017.2.21,77: e12632

  (5) Wang, Kai(#) ,Diao, Liang-Hui(#) ,Gong, Yu,Liu, Xin,Li, Yingqiu(*),NEMO differentially regulates TCR and TNF-alpha induced NF-kappaB pathways and has an inhibitory role in TCR-induced NF-kappaB activation.,Cell Signal,2012.8.01,24(8): 1556~1564

  2. 既非第一作者又非通讯作者论文

  (1) Xu, Yanhong, Jie Mei, Lianghui Diao, Yuye Li, and Lijun Ding(*). Chronic Endometritis and Reproductive Failure: Role of Syndecan‐1. American Journal of Reproductive Immunology 84, no. 3 (2020): e13255.

  (2) Chen, Xian, Lianghui Diao, Ruochun Lian, Lingbin Qi, Shuyi Yu, Su Liu, Shenglai Lin, Zhigang Xue(*), and Yong Zeng(*). "Potential Impact of Maternal Vitamin D Status on Peripheral Blood and Endometrium Cellular Immunity in Women with Recurrent Implantation Failure." American Journal of Reproductive Immunology (2020): e13243.

  (3) Liu, Su(#), Hongxia Wei(#), Yuye Li, Lianghui Diao, Ruochun Lian, Xu Zhang, and Yong Zeng(*). "Characterization of Dendritic Cell (Dc) 10 in Recurrent Miscarriage and Recurrent Implantation Failure." Reproduction 1, no. aop (2019).

  (4) Wang, Linlin(#), Longfei Li(#), Chunyu Huang, Lianghui Diao, Ruochun Lian, Yuye Li, Shan Xiao, et al. "Maternal Chronic Hepatitis B Virus Infection Does Not Affect Pregnancy Outcomes in Infertile Patients Receiving First in Vitro Fertilization Treatment." Fertility and sterility 112, no. 2 (2019): 250-57. e1.

  (5) Zhu, Yuanchang, Qing Liu, Meijian Liao, Lianghui Diao, Tonghua Wu, Weijie Liao, Ziqiang Wang, et al. "Overexpression of Lncrna Epb41l4a-As1 Induces Metabolic Reprogramming in Trophoblast Cells and Placenta Tissue of Miscarriage." Molecular Therapy-Nucleic Acids 18 (2019): 518-32.

  (6) Thiele Kristin, Diao, Liang-Hui, Arck, Petra(*), Immunometabolism, pregnancy, and nutrition, Seminars in immunopathology, 2017, pp. 1-18.

  (7) Liu, Su, Diao, Liang-Hui, Huang, Chunyu , Li, Yuye, Zeng, Yong, Kwak-Kim, Joanne. The role of decidual immune cells on human pregnancy, Journal of reproductive immunology 124 (2017) 44-53.

  (8) Chen, Xian(#),Yin, Biao(#),Lian, Ruo-Chun,Zhang, Tao,Zhang, Hong-Zhan,Diao, Liang-Hui,Li, Yu-Ye,Huang, Chun-Yu ,Liang, De-Sheng(*),Zeng, Yong(*),Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage., Am J Reprod Immunol,2016.12.01,76(6):432~438

  (9) Huang, Chunyu(#),Zhang, Hongzhan(#),Chen, Xian,Diao, Lianghui,Lian, Ruochun, 4 Zhang, Xu,Hu, Lina(*),Zeng, Yong(*),Association of peripheral blood dendritic cells with recurrent pregnancy loss: a case-controlled study.,Am J Reprod Immunol,2016.10.01,76 (4):326~332

  (10) Liang, Pei-Yan(#),Diao, Liang-Hui,Huang, Chun-Yu ,Lian, Ruo-Chun,Chen, Xian,Li, Guan-Gui,Zhao, Jin,Li, Yu-Ye,He, Xue-Bing,Zeng, Yong(*),The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure.,Reprod Biomed Online,2015.12.01,31(6):823~826

  编著

  Diao, Lianghui; Cai, Songchen; Ding, Jinli; Zeng, Yong; Metabolic and Nutritional Impact on Endometrial Gene Expression and Reproductive Disorder, Endometrial Gene Expression,2020, (199-214)

  大会报告(大会口头报告)

  (1)Lianghui Diao; The Immunometabolism of early pregnancy - evidence from dendritic cells and regulatory T cells, 第一届(2019)母胎医学科学研究大会(厦门), 厦门大学, 2019-12-6 至 2019-12-9. (大会报告)

  (2)Lianghui Diao; Maria Emilia Solano; Yong Zeng; Kristin Thiele; Petra Arck; The immune metabolic adaptations during early pregnancy: lessons learned from tumor immunology, The 38th Annual Meeting of the American Society for Reproductive Immunology, 上海, 2018-6-28 至 2018-7-1. (大会报告)

  授权专利

  (1)曾勇; 刁梁辉; 黄春宇; 李玉叶; 连若纯; 一种子宫血管阻断钳, 2020-3-31, 中国, ZL 2019 2 0201722. 1. (发明专利)

  (2)黄春宇; 刁梁辉; 陈现; 李玉叶; 连若纯; 陈聪; 一种用于评估子宫内膜容受性的试剂盒及其使用方法, 2017-10-31, 中国, ZL 2016 1 0021908. X. (发明专利)