刁梁辉
刁梁辉

姓名:刁梁辉
职称/头衔:博士
所属科室:生殖医学临床研究中心/生殖免疫中心
从业年限:
技术专长:子宫内膜接受性的生物标记物筛选,子宫内膜微环境的免疫学调控机制及反复胚胎着床失败的临床干预策略

个人简介

  深圳中山泌尿外科医院生殖医学临床研究中心主任/生殖免疫中心负责人。2012年获中山大学生命科学学院生物化学与分子生物学理学博士学位。毕业后即加入深圳中山泌尿医院生殖医学中心从事生殖免疫学研究。2017-2018年期间在德国汉堡大学艾本德医院母胎医学中心接受博士后训练,研究内容为免疫细胞代谢信号通路对妊娠早期免疫耐受微环境建立的作用机制,合作导师为Petra Arck教授。

  研究方向:

  研究方向为子宫内膜接受性的生物标记物筛选,子宫内膜微环境的免疫学调控机制及反复胚胎着床失败的临床干预策略。

  学术成果:

  截至2018年7月,主持国家自然科学青年基金1项(2018-2020),广东省科技发展专项资金项目1项(2017-2019),结题默克雪兰诺中囯生殖医学研究基金(CREATE)1项(2015-2017),深圳市科技创新委基础研究项目1项(2014-2016)和深圳市卫生与计划生育委员会临床研究项目1项(2016-2018年)。担任Seminars in Immunopathology、American Journal of Reproductive Immunology和 Journal of Reproductive Immunology 等杂志审稿人。以第一作者和共同作者发表SCI论文十余篇,获授权发明专利1项,在审发明专利3项。以参与者身份获深圳市科技进步奖1项(2015年)。

  代表性论文列表如下:

  1) K. Thiele, L. Diao, P.C. Arck, Immunometabolism, pregnancy, and nutrition, Seminars in immunopathology, Springer Berlin Heidelberg, 2017, pp. 1-18. (Review)

  2) S. Liu, L. Diao, C. Huang, Y. Li, Y. Zeng, J.Y. Kwak-Kim, The role of decidual immune cells on human pregnancy, Journal of reproductive immunology 124 (2017) 44-53.

  3) Ding J L1, Diao L H1, Yin T L, Huang C Y, Yin B, Chen C, Zhang Y, Li J, Cheng Y X, and Zeng Y*. 2017. Aberrant expressions of endometrial Id3 and CTLA‐4 are associated with unexplained repeated implantation failure and recurrent miscarriage. American Journal of Reproductive Immunology 77: e12632. (co-first author)

  4) Diao L H, Li G G, Zhu Y C, Tu W W, Huang C Y, Lian R C, Chen X, Li Y Y, Zhang T, and Huang Y. 2017. Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells. American Journal of Reproductive Immunology 77: e12618.

  5) Huang C1, Zhang H1, Chen X, Diao L, Lian R, Zhang X, Hu L, and Zeng Y*. 2016. Association of peripheral blood dendritic cells with recurrent pregnancy loss: a case‐controlled study. American Journal of Reproductive Immunology 76: 326-332.

  6) Chen X1, Yin B1, Lian R C, Zhang T, Zhang H Z, Diao L H, Li Y Y, Huang C Y, Liang D S, and Zeng Y. 2016. Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage. American Journal of Reproductive Immunology 76: 432-438.

  7) Wang X-D1, Gong Y1, Chen Z-L1, Gong B-N1, Xie J-J, Zhong C-Q, Wang Q-L, Diao L-H, Xu A, Han J and Li Y*(2015) TCR-induced sumoylation of the kinase PKC-[theta] controls T cell synapse organization and T cell activation. Nature immunology 16, 1195–1203 (2015)

  8) Liang P-Y, Diao L-H, Huang C-Y, Lian R-C, Chen X, Li G-G, Zhao J, Li Y-Y, He X-b, Zeng Y* (2015) The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure. Reproductive biomedicine online 31(6):823-6.

  9) Huang C, Liang P, Diao L, Liu C, Chen X, Li G, Chen C, Zeng Y* (2015) Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure. International journal of environmental research and public health 12: 10352-10361

  10) Wan C-Y1, Song C1, Diao L-H, Li G-G, Bao Z-J, Hu X-D, Zhang H-Z, Zeng Y* (2014) Laser-assisted hatching improves clinical outcomes of vitrified–warmed blastocysts developed from low-grade cleavage-stage embryos: a prospective randomized study. Reproductive biomedicine online 28: 582-589

  11) Xie J-J1, Liang J-Q1, Diao L-H, Altman A, Li Y* (2013) TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. The Journal of Immunology 190: 4027-4036

  12) Wang K1, Diao L-H1, Gong Y, Liu X, Li Y* (2012) NEMO differentially regulates TCR and TNF-α induced NF-κB pathways and has an inhibitory role in TCR-induced NF-κB activation. Cellular signalling 24: 1556-1564 (co-first author)